Approximately 20 percent of all canine lameness is due to inflammatory stifle arthritis and associated degenerative cruciate ligament rupture. The public spends an estimated $1 billion per year on medical and surgical treatments for this condition.
Yet, despite extensive research over the years, the prognosis for dogs that receive surgery for this problem remains moderate in the medium to long-term, no matter what surgical treatment is used.
Now, with the goal of developing improved treatment for cruciate rupture, veterinary orthopedic specialists at the UW-Madison School of Veterinary Medicine are approaching the problem in a new way.
“Our work suggests that joint inflammation precedes development of cruciate rupture, whereas the traditional view has been that joint inflammation is a consequence of the joint instability from cruciate rupture,” says Dr. Peter Muir an orthopedic surgeon at the UW-Madison School of Veterinary Medicine.
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As a result, Dr. Muir and his colleagues in the school’s Comparative Orthopaedic Research Laboratory are concentrating on finding stifle joint inflammation earlier, before the development of instability. (The stifle joint corresponds to the knee joint in humans.) They postulate that medical treatment that blocks joint degeneration and keeps the stifle joint stable over time will improve outcome.
Dr. Muir is also investigating whether there may be a genetic predisposition to this form of inflammatory arthritis, as is the case in humans with rheumatoid arthritis.
